BCOM - British College of Osteopathic Medicine

Osteonet

BCOM's Student Extranet

Senior Management

  Dr Kerstin Rolfe RGN, BSc (Hons), PhD, LLM

  Principal, Head of Research

    Subject: Research Methods, Ethics, Physiology, Practice Management

    Contact: For enquiries please contact Mrs Van Treptow vtreptow@bcom.ac.uk

  



Dr Kerstin Rolfe started her career as a nurse working on a busy gynaecological ward. Her interest in research grew when she was appointed as a MRC Clinical Research Nurse to project manage a multi-centred surgical trial and a pharmaceutical trial. During this time she undertook a part-time BSc (Hons) in Biological Sciences. Her working career moved to running an ovarian scanning unit for women at high risk of developing ovarian cancer. Following attainment of her BSc (Hons) she was awarded a scholarship to undertake a PhD in molecular pathology in a gynaecological cancer unit which she did at the Royal Free Hospital whilst registered at UCL.

Her postgraduate career involved studying tissue regeneration, wound healing and adhesion formation in tendons and skin. She has supervised a number of surgeons helping them attain their postgraduate qualification. She is currently co-supervising two post-graduate medical students enrolled on PhDs through UCL. She has further studied and been awarded a LLM in Medical Law and Ethics.

Kerstin is on a number of journal editorial boards and is currently the Editor in Chief for Bone and Tissue Regeneration Insights.

Full Publications and Chapters

Drysdale IP, Hinkley H, Rolfe KJ. Patient perception of osteopathic training in the UK and patient reported experience. IJOM. In press

Branford O, Grobbelaar AO, Rolfe KJ. The growth factors involved in flexor tendon repair and adhesion formation. J Hand Surg (Eur) In press

Klass BR, Rolfe KJ, Grobbelaar AO. The role of EGCG in preventing tendon adhesion. J Hand Surg (Eur) Submitted.

Grobbelaar AO, Rolfe KJ.  A review of fetal scarless healing. ISRN Dermatology. 2012; 2012:698034

Branford OA, Rolfe KJ, Grobbelaar AO Epigallocatechin 3 galalte (EGCG) a constituent of green tea and its anti-fibrotic effect. In Tea Consumption and health. (Ed Banerjee G) Nova Publishing 2012

Penn JW, Grobbelaar AO, Rolfe KJ. The role of the TGF-β family in wound healing, burns and scarring a review.  Int J Burn Trauma 2012; 2: 18-28

Branford OA, Lee DA, Rolfe KJ, Grobbelaar AO. The attachment of intrinsic and extrinsic, mobilised and immobilised adhesion cells to collagen and fibronectin. J Hand Surg (Eur) 2012; 37: 564-72

Penn J, Grobbelaar AO, Rolfe KJ. Skin  Regeneration: the Possibilities. Recent Patents  Regen Med. 2011; 1: 164-172

 Grobbelaar AO, Rolfe KJ. The growth receptors and their role in wound healing. Curr Opin Investig Drugs 2010; 11: 121-8

Klass BR, Branford O, Grobbelaar AO, Rolfe KJ. EGCG does it have a role in preventing wound contracture. Wound Repair Regen. 2010: 18; 80-8

Rolfe KJ, Grobbelaar AO. Invited Commentary: TGF-b1 – Induced expression of the anti-apoptotic PAI-1 protein requires EGFR signalling. Cell Communications Insights. 2009: 2 13-15

Klass BR, Rolfe KJ, Grobbelaar AO. The in vitro flexor tendon cell response to TGF-β1: A gene expression study of tendon healing and adhesion prevention J Hand Surg (Am). 2009: 34; 495-503

Klass BK, Grobbelaar AO, Rolfe KJ. TGF-b1 signalling wound repair and scarring. A delicate balance. Post Grad Med J. 2009; 85:9-14

Rolfe KJ, Grobbelaar AO. TGF-β1 and cell proliferation. Chapter in Handbook of Cell Proliferation. (Eds Briggs and Coburn) Nova Publishers. 2009; 331-352

Ellis PE, MacLean AB, Crow JC, Wong LF, Rolfe KJ et al. Cyclin D1 and retinoblastoma protein expression in Paget’s disease of the vulva and breast. Histopathol.2009; 55:709-15

Rolfe KJ. Editorial. BTRI 2008:1

Rolfe KJ et al. A role for TGF-β1-induced cellular responses in the early non-scarring fetus. J Invest Dermatol 2007; 127:2656-67

Rolfe KJ et al. Insulin like growth factors exhibit different effects on fetal dermal fibroblasts than postnatal dermal fibroblasts. BMC Dev Biology  2007; 7: 124

Rolfe KJ et al. Differential gene expression in response to TGF-β1 by fetal and postnatal dermal fibroblasts. Wound Repair and Regen 2007; 15:897-906.

Cited in: Faculty of 1000 Biology: www.f1000biology.com/article/id/1097075

Eva LJ, MacLean AB, Rolfe KJ, Wong Te Fong A-C et al. Localized provoked vulvodynia is not an inflammatory condition. J Reprod Med 2007; 52:379-84

MacLean AB, Rolfe KJ. Markers of malignant change in some vulvar dermatoses. A Review. CME Journal of Gynecologic Oncology 2005; 10;169-172

Linge C, Richardson J, Vigor C, Clayton E, Hardas B, Rolfe K. Hypertrophic scars fail to undergo apoptosis specific to contractile collagen – the role of transglutaminase.  J Invest Dermatol 2005; 125 71-78

Saravanamuthu J, Reid WMN, St George D, Crow JCC, Rolfe KJ, et al. The role of angiogenesis in vulvar cancer, vulvar intraepithelial neoplasia and vulvar lichen sclerosus as determined by microvessel density analysis. Gynecol Oncol  2003; 89: 251-258

Rolfe KJ et al. TP53 mutations in vulval lichen sclerosus adjacent to squamous cell carcinoma of the vulva. Br J Cancer 2003; 89, 2249-53

Eva LJ, MacLean AB, Reid WMN, Rolfe KJ. The role of estrogen receptors in vulvar vestibulitis. Am J Obstet Gynecol 2003; 189: 458-61

Dos Santos Silva I, MacLean AB, Mayer D, Hardiman PJ, Lieberman G, Nieto JJ, Parsons M, Rolfe K, Ginsburg J. Does ovarian stimulation increase the risk of ovarian cancer? Reprod Med Rev 2002; 11: 57-66

Ellis PE., Wong Te Fong LF, Rolfe KJ et al. The role of p53 and Ki67 in Paget’s disease of the vulva and the breast. Gynecol Oncol 2002; 86: 150-6

Ellis PE, Wong Te Fong LF, Rolfe KJ et al. The role of vascular endothelial growth factor-A (VEGF-A) and platelet derived endothelial cell growth factor/Thymidine phosphorylase (PD-ECGF/TP) in Paget’s disease of the vulva and breast. Anticancer Res. 2002; 22: 857-861

Rolfe KJ et al.  Is there a link between vulval cancer and blood group? Eur J Gynaecol Cancer. 2002; 23:111-112

Rolfe KJ et al. The effect of topical steroids on Ki-67 and p53 expression in vulval lichen sclerosus. Br J Dermatol. 2002; 147: 503-8

Levine T, Rolfe KJ et al. The use of cytospin monolayer technique in the cytological diagnosis of vulval disease. Cytopathol 2001; 12:297-305

Rolfe KJ et al.  Cell Cycle Proteins as Molecular Markers of Malignant Change in Lichen Sclerosus. Int J Gynecol Cancer. 2001; 11: 113-118

Rolfe KJ et al. Cyclin D1 and retinoblastoma in vulval cancer. Int J Gynecol Cancer. 2001; 11:381-386

MacLean AB, Reid WMN, Rolfe KJ et al. The role of angiogenesis in benign, premalignant and malignant vulvar lesions. J Reprod Med 2000; 45: 609-612

Chaberek S, Kolasinska AD, Rolfe KJ et al. Correlation between cyclin D1 expression and renal cell cancer (RCC) prognostic factors. Initial Study. Urologia Polska 2000: 53:1

Nieto JJ, Rolfe KJ et al. Ovarian cancer and infertility-a genetic link?  Lancet 1999; 354: 649

Rolfe KJ et al. Ovarian intraepithelial dysplasia in relation to ovulation patterns. Contemp Rev Obs and Gynecol 1999; 11: 113-117

Ferreux E, Rolfe KJ et al. Analysis cell cycle and apoptosis proteins in ovarian cancer. J Pathol 1997; 181: A55

Broadbent JA, Hill NK, Molnar BG, Rolfe KJ, Magos AL. Randomised Placebo controlled trial to assess the role of intracervical lignociane in outpatient hysteroscopy.  Br J Obstet Gynaecol 1992; 99: 777-9

 
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